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c-Fos expression in rat brainstem following intake of sucrose or saccharin

Ke Chen, Jianqun Yan, Jinrong Li, Bo Lv, Xiaolin Zhao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 294-301 doi: 10.1007/s11684-011-0144-8

Abstract: post-ingestive factors, we compared the distribution of c-Fos-like immunoreactivity (c-FLI) in the nucleusof the solitary tract (NST) and parabrachial nucleus (PBN) of brainstem following ingestion of 0.25

Keywords： c-Fos     parabrachial     the nucleus of the solitary tract     sweet tastant     rat    

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miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 317-322 doi: 10.1007/s11684-010-0035-4

Abstract: It is suggested that the digestive tract congestion injury caused by liver ischemia can upregulate the

Keywords： hepatic ischemia-reperfusion     digestive tract congestion     cholecystokinin     vasoactive intestinal peptide    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: Cystic fibrosis (CF) is a rare autosomal recessive disease with only one pathogenic gene cystic fibrosis transmembrane conductance regulator (CFTR). To identify the potential pathogenic mutations in a Chinese patient with CF, we conducted Sanger sequencing on the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR and their flanking intronic regions. The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9. The splicing effect of c.1210-3C>G was verified via minigene assay in vitro, indicating that wild-type plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon 10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence caused almost all mRNA to skip exon 10. Overall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5 sequence in cis, affects the CFTR gene splicing and produces nearly no normal transcript in vitro. Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation in Chinese patients with CF.

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: However, the combined expression of GATA3 and microsatellite instability (MSI) in upper tract urothelial

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 516-520 doi: 10.1007/s11705-017-1658-7

Abstract: of three chambers representing stomach, duodenum, and jejunum, to create the human gastrointestinal tract-like

Keywords： GIS     in vivo predictive dissolution     ketoconazole     BCS subclassification     supersaturation    

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The role of fusion-fission hybrid reactor in development of China nuclear energy resources

Liu Cheng’an,Shi Xueming

Strategic Study of CAE 2011, Volume 13, Issue 3,   Pages 24-28

Abstract:

The strategic position of the nuclear energy in the development of China energy resources and the important role of the fusion-fission hybrid reactors in the sustained development of nuclear energy resources are analyzed. The hybrid reactor with ITER fusion device as driving reactor core which could be realized in near future and water-cooled natural uranium fission system as blanked is discussed. With hybrid reactor the 1 GWe net electrical power output and yearly fissile fuel production 1 656 kg that could meet need of 2.68 PWR(pressurized water reactors)for fissile fuel could be attained. A rough economic estimation predict that capital cost of hybrid reactor is 1.67 times as large as capital cost of same power PWR without including the cost of nuclear fuel; the electrical cost of combined system of hybrid reactor and PWR is 1.18 times of electrical cost of same power PWR. Considering cost of fissile fuel that PWR consume, the electricity cost of combined system of hybrid reactor and PWR could be competitive with PWR electricity cost.

Keywords： hybrid reactor     fusion reactor core     fission blanked     fissile nucleus     fissionable nucleus    

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Mechanisms of the spatial memory deficits induced by injection of okadaic acid into the Meynert nucleus

TIAN Qing, LIU Bin, ZHOU Xinwen, TU Qian, LIU Rong, WANG Jianzhi

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 147-153 doi: 10.1007/s11684-008-0028-8

Abstract: We previously reported that the injection of okadaic acid (OA) into the Meynert nucleus basalis of ratsacetylcholine (Ach) in the hippocampus significantly decreased 24 h after injection of OA into the Meynert nucleusIt is suggested that injection of OA into the Meynert nucleus basalis of rats may impair the hippocampus-dependentspatial memory through damaging the cholinergic projection between the Meynert nucleus basalis and the
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Serologic study on the outbreak of acute upper respiratory tract infections caused by adenovirus 3

JIANG Lufang, JU Liwen, LIN Yuzun, ZHOU Liandi, YU Shunzhang, JIANG Qingwu, JIANG Renjie

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 215-218 doi: 10.1007/s11684-007-0041-3

Abstract: From April to June, 2004, an outbreak of acute upper respiratory tract infections (AURTI) occurred in

Keywords： Twenty     Adenovirus     cytopathogenic     type-specific     AURTI    

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Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 264-268 doi: 10.1007/s11684-008-0050-x

Abstract: preparation procedure of brainstem slices and the spontaneous firing properties of rat medial vestibular nucleus

Keywords： resistance     infrared     infrared videomicroscopy     depressive     after-hyperpolarization potential    

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The prevalence of reproductive tract infection among floating women of childbearing age in Urumqi

Zhang Junxian,Zhou Yanling,Liu Jians,Wang Shan,Li Li,Mei Gui,Li Lin and Bahaguli·Tajimanti

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 85-89

Abstract:

To understand the prevalence of reproductive tract infection (RTI) of

Keywords： floating women of childbearing age     reproductive tract infection     prevalence    

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Fastigial Nucleus Electrical Stimulation and Central Neurogenic Neuroprotection

Dong Weiwei

Strategic Study of CAE 2001, Volume 3, Issue 11,   Pages 32-38

Abstract: central neurogenic neuroprotection, which is represented in intrinsic neurons in cerebellar fastigial nucleusIt can be initiated by electrical excitation of intrinsic neurons of fastigial nucleus and afford a persistingSome prelimilary observations of clinical application of fastigial nucleus electrical stimulation onRecommendations of further research on fastigial nucleus stimulation before its broad clinical practice

Keywords： neuroprotection     conditioned     fastigial neucleus     stimulation     cerebral ischemia    

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Title Author Date Type Operation

c-Fos expression in rat brainstem following intake of sucrose or saccharin

Ke Chen, Jianqun Yan, Jinrong Li, Bo Lv, Xiaolin Zhao

Journal Article

miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Journal Article

The role of fusion-fission hybrid reactor in development of China nuclear energy resources

Liu Cheng’an,Shi Xueming

Journal Article

Mechanisms of the spatial memory deficits induced by injection of okadaic acid into the Meynert nucleus

TIAN Qing, LIU Bin, ZHOU Xinwen, TU Qian, LIU Rong, WANG Jianzhi

Journal Article

Serologic study on the outbreak of acute upper respiratory tract infections caused by adenovirus 3

JIANG Lufang, JU Liwen, LIN Yuzun, ZHOU Liandi, YU Shunzhang, JIANG Qingwu, JIANG Renjie

Journal Article

Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual

XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai

Journal Article

The prevalence of reproductive tract infection among floating women of childbearing age in Urumqi

Zhang Junxian,Zhou Yanling,Liu Jians,Wang Shan,Li Li,Mei Gui,Li Lin and Bahaguli·Tajimanti

Journal Article

Fastigial Nucleus Electrical Stimulation and Central Neurogenic Neuroprotection

Dong Weiwei

Journal Article